Manuscripts

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Activity of omadacycline tested against Streptococcus pneumoniae from a global surveillance program (2014)
Pfaller et al.
Diagnostic Microbiology & Infectious Disease
Published online Oct 19, 2017

 

Pharmacokinetics and Safety of Omadacycline in Subjects With Impaired Renal Function
Berg et al.
Antimicrob. Agents Chemother
Published online Nov 20, 2017

 

Safety and Pharmacokinetics of the Aminomethylcycline Antibiotic Omadacycline Administered to Healthy Subjects in Oral Multiple Dose Regimens
Bundrant et al.
Antimicrob. Agents Chemother
Published online Nov 27, 2017

 

Comparison of Omadacycline and Tigecycline Pharmacokinetics in the Plasma, Epithelial Lining Fluid, and Aveolar Cells in Healthy Adult Subjects

Gotfried, M.H., Horn, K., Garrity-Ryan, L., Villano, S., Tzanis, E., Chitra, S., Manley, A., Tanaka, S.K., Rodvold, K.A.
Antimicrob. Agents Chemother.  doi:10.1128/AAC.01135-17
Published online 10 July 2017

 

Surveillance of Omadacycline Activity against Clinical Isolates from a Global Collection (North America, Europe, Latin America, Asia-Western Pacific), 2010-2011

Pfaller, M.A., Huband, M.D., Rhomberg, P.R., Flamm, R.K.
Antimicrob. Agents Chemother.  doi:10.1128/AAC.00018-17
Published online 21 February 2017

 

In Vitro and In Vivo Activity of Omadacycline Against Two Biothreat Pathogens: Bacillus anthracis and Yersinia Pestis

Steenbergen, J., Tanaka, S.K., Miller, L.L., Halasohoris, S.A., Hershfield, J.R. 
Antimicrob. Agents Chemother.  doi:10.1128/AAC.02434-16
Published online 21 February 2017

 

In vivo Pharmacodynamic Evaluation of Omadacycline (PTK 0796) against Streptococcus pneumoniae in the Murine Pneumonia Model 

Lepak, A.J., Zhao, M., Marchillo, K., VanHecker, J., Andes, J.R.
Antimicrob. Agents Chemother.  doi:10.1128/AAC.02368-16
Published online 13 February 2017

 

Activity of Omadacycline and Comparator Agents When Tested against Staphylococcus aureus from a Surveillance Program Conducted in North America and Europe

Pfaller, M.A., Rhomberg, P.R., Huband, M.D., Flamm, R.K.
Antimicrob. Agents Chemother.  doi:10.1128/AAC.02411-16
Published online 19 December 2016

 

Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline Following a Single Intravenous or Oral Dose of 14C-omadacycline in Rats

Lin W., Flarakos J., Du Y., Hu W., He H., Mangold J., Tanaka S.K., Villano S.
Antimicrob. Agents Chemother.  doi:10.1128/AAC.01784-16
Published online 7 November 2016

 

A Randomized, Open-label Study of the Pharmacokinetics and Safety of Oral and Intravenous Administration of Omadacycline to Healthy Subjects

Sun H., Ting L., Machineni S., Praestgaard J., Kuemmell A., Stein D.S., Sunkara G., Kovacs S.J.,Villano S., Tanaka S.K.
Antimicrob. Agents Chemother. doi:10.1128/AAC.01393-16
Published online 10 October 2016

 

In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents Against Human Mycoplasmas and Ureaplasmas

Waites K., Crabb D., Liu Y., Duffy L.
Antimicrob. Agents Chemother. AAC.01734-16
Published online 26 September 2016

 

The Novel Aminomethylcycline Omadacycline Has High Specificity for the Primary Tetracycline-Binding Site on the Bacterial Ribosome

Heidrich C.G., Mitova S., Schedlbauer A., Connell S.R., Fucini P., Steenbergen J.N., Berens C
Antibiotics 2016, 5, 32, doi:10.3390/antibiotics5040032  
Published online 22 September 2016

 

Effect of Food on the Bioavailability of Omadacycline in Healthy Subjects

Tzanis, E., Manley, A., Villano, S., Tanaka, S.K., Bai, S., Loh, E.
The Journal of Clinical Pharmacology 2017, 57(3) 321-327, doi:10.1002/jcph.814
Published online 19 August 2016

 

Omadacycline: development of a novel aminomethylcycline antibiotic for treating drug-resistant bacterial infections

S. Villano, J. Steenbergen and E. Loh
Future Microbiol., 11(11), 1421–1434
Published online 19 August 2016

  

Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline

J. Flarakos, Y. Du, H. Gu, L. Wang, H. J. Einolf, D. Y. Chun, B. Zhu, N. Alexander, A. Natrillo, I. Hanna, L. Ting, W. Zhou, K. Dole, H. Sun, S. J. Kovacs, D. S. Stein, S. K. Tanaka, S. Villano, and J. B. Mangold
Xenobiotica, DOI: 10.1080/00498254.2016.1213465
Published online 3 August 2016

 

Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibiotic

S. Ken Tanaka, Judith Steenbergen, Stephen Villano
Bioorganic & Medicinal Chemistry, 24 (2016) 6409–6419
Published online 18 July 2016
S.K. Tanaka, S. Villano
Antimicrobial Agents and Chemotherapy, 60(9):5247-5253, doi:10.1128/AAC.00320-16
Published online 20 June 2016

 

Structure-Activity Relationship of the Aminomethylcyclines and Discovery of Omadacycline
L. Honeyman, M. Ismail, M. Nelson, B. Bhatia, T.E. Bowser, J. Chen, R. Mechiche, K. Ohemeng, A.K. Verma, E.P. Cannon, A. Macone, S.K. Tanaka, and S. Levy
Antimicrobial Agents and Chemotherapy
November 2015, 59:7044-7053

 

Mechanism of Action of the Novel Aminomethylcycline Antibiotic Omadacycline
M.P. Draper, S. Weir, A. Macone, J. Donatelli, C.A. Trieber, S.K. Tanaka, and S.B. Levy
Antimicrobial Agents and Chemotherapy
March 2014, 58(3): 1279–1283

 

In Vitro and In Vivo Antibacterial Activities of Omadacycline, a Novel Aminomethylcycline
A.B. Macone, B.K. Caruso, R.G. Leahy, J. Donatelli, S. Weir, M.P. Draper, S.K. Tanaka, and S. B. Levy
Antimicrobial Agents and Chemotherapy
February 2014, 58(2): 1127–1135

 

A Randomized, Evaluator-Blind, Phase 2 Study Comparing the Safety and Efficacy of Omadacycline to Those of Linezolid for Treatment of Complicated Skin and Skin Structure Infections
G.J. Noel, M.P.  Draper, H. Hait, S.K. Tanaka, and R.D. Arbeit
Antimicrobial Agents and Chemotherapy
November 2012, 56(11): 5650–5654