Manuscripts

Click here to download the complete bibliography with links to articles

 

Minimal inhibitory concentration of omadacycline and doxycycline against bacterial isolates with known tetracycline resistance determinants
Fluit et al.
Diagnostic Micro. & Infect. Dis. doi: 10.1016/j.diagmicrobio.2018.11.010
Published online 29 November 2018


Omadacycline gut microbiome exposure does not induce Clostridium difficile proliferation or toxin production in a model that simulates the proximal, medial and distal human colon
Antimicrob. Agents Chemother. doi: 10.1128/AAC.01581-18
Published online 19 November 2018

 

Activity of Omadacycline Tested against Enterobacteriaceae Causing Urinary Tract Infections from a Global Surveillance Program (2014)
Pfaller et al.
Diagnostic Micro. & Infect. Dis. doi: 10.1016/j.diagmicrobio.2018.01.019
Published online 28 February 2018

 

Omadacycline: comparative in vitro activity against dog and cat bite wound isolates
Goldstein et al.
Antimicrob. Agents Chemother. doi: 10.1128/AAC.02551-17
Published online 12 February 2018

 

The In Vitro Activity of Omadacycline and Comparators Against Anaerobic Bacteria
Stapert et al.
Antimicrob. Agents Chemother. doi: 10.1128/AAC.00047-18
Published online 12 February 2018

 

Surveillance of omadacycline activity tested against clinical isolates from the United States and Europe: Report from the SENTRY Antimicrobial Surveillance Program (2016)
Pfaller et al. 
Antimicrob. Agents Chemother. doi: 10.1128/AAC.02327-17
Published online 29 January 2018

 

Safety and Pharmacokinetics of the Aminomethylcycline Antibiotic Omadacycline Administered to Healthy Subjects in Oral Multiple Dose Regimens
Bundrant et al.
Antimicrob. Agents Chemother. doi: 10.1128/AAC.01487-17
Published online 27 November 2017

 

Pharmacokinetics and Safety of Omadacycline in Subjects With Impaired Renal Function
Berg et al.
Antimicrob. Agents Chemother. doi: 10.1128/AAC.02057-17
Published online 20 November 2017

 

Activity of omadacycline tested against Streptococcus pneumoniae from a global surveillance program (2014)
Pfaller et al.
Diagnostic Micro. & Infect. Dis. doi: 10.1016/j.diagmicrobio.2017.10.010
Published online 19 October 2017

 

Comparison of Omadacycline and Tigecycline Pharmacokinetics in the Plasma, Epithelial Lining Fluid, and Aveolar Cells in Healthy Adult Subjects
Gotfried,et al. 
Antimicrob. Agents Chemother. doi:10.1128/AAC.01135-17
Published online 10 July 2017

 

Surveillance of Omadacycline Activity against Clinical Isolates from a Global Collection (North America, Europe, Latin America, Asia-Western Pacific), 2010-2011
Pfaller et al.
Antimicrob. Agents Chemother. doi:10.1128/AAC.00018-17
Published online 21 February 2017

 

In Vitro and In Vivo Activity of Omadacycline Against Two Biothreat Pathogens: Bacillus anthracis and Yersinia Pestis
Steenbergen et al.
Antimicrob. Agents Chemother. doi:10.1128/AAC.02434-16
Published online 21 February 2017

 

In vivo Pharmacodynamic Evaluation of Omadacycline (PTK 0796) against Streptococcus pneumoniae in the Murine Pneumonia Model 

Lepak et al.
Antimicrob. Agents Chemother. doi:10.1128/AAC.02368-16
Published online 13 February 2017

 

Activity of Omadacycline and Comparator Agents When Tested against Staphylococcus aureus from a Surveillance Program Conducted in North America and Europe

Pfaller et al.
Antimicrob. Agents Chemother. doi:10.1128/AAC.02411-16
Published online 19 December 2016

 

Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline Following a Single Intravenous or Oral Dose of 14C-omadacycline in Rats

Lin et al.
Antimicrob. Agents Chemother. doi:10.1128/AAC.01784-16
Published online 7 November 2016

 

A Randomized, Open-label Study of the Pharmacokinetics and Safety of Oral and Intravenous Administration of Omadacycline to Healthy Subjects

Sun et al.
Antimicrob. Agents Chemother. doi:10.1128/AAC.01393-16
Published online 10 October 2016

 

In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents Against Human Mycoplasmas and Ureaplasmas

Waites et al.
Antimicrob. Agents Chemother. doi: 10.1128/AAC.01734-16
Published online 26 September 2016

 

The Novel Aminomethylcycline Omadacycline Has High Specificity for the Primary Tetracycline-Binding Site on the Bacterial Ribosome

Heidrich et al.
Antibiotics doi:10.3390/antibiotics5040032
Published online 22 September 2016

 

Effect of Food on the Bioavailability of Omadacycline in Healthy Subjects

Tzanis et al.
J. Clin. Pharmacol. doi:10.1002/jcph.814
Published online 19 August 2016

 

Omadacycline: development of a novel aminomethylcycline antibiotic for treating drug-resistant bacterial infections

Villano et al.
Future Microbiol. doi: 10.2217/fmb-2016-0100
Published online 19 August 2016

  

Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline

Flarakos et al.
Xenobiotica doi: 10.1080/00498254.2016.1213465
Published online 3 August 2016

 

Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibiotic

Tanaka et al.
Bioorg. Med. Chem. doi: 10.1016/j.bmc.2016.07.029
Published online 18 July 2016

 

Tanaka et al.
Antimicrob. Agents Chemother. doi:10.1128/AAC.00320-16
Published online 20 June 2016

 

Structure-Activity Relationship of the Aminomethylcyclines and Discovery of Omadacycline
Honeyman et al.
Antimicrob. Agents Chemother. doi: 10.1128/AAC.01536-15
Published online 8 September 2015

 

Mechanism of Action of the Novel Aminomethylcycline Antibiotic Omadacycline
Draper et al.
Antimicrob. Agents Chemother. doi: 10.1128/AAC.01066-13
Published online 16 September 2013

 

In Vitro and In Vivo Antibacterial Activities of Omadacycline, a Novel Aminomethylcycline
Macone et al.
Antimicrob. Agents Chemother. doi: 10.1128/AAC.01242-13
Published online 2 Dec 2013